Photosensitization of Colpoda inflata cysts by meso-substituted cationic porphyrins.
Photochem Photobiol Sci
; 1(8): 560-4, 2002 Aug.
Article
in En
| MEDLINE
| ID: mdl-12659497
ABSTRACT
Colpoda inflata cysts accumulate significantly large amounts of meso-substituted cationic porphyrins, including meso-tetrakis(N-methyl-4-pyridyl)porphine (TMP-C1) and its mono-N-methyldecyl (TMP-C10) and -tetradecyl (TMP-C14) analogues upon incubation for 1 h with 1-48 microM porphyrin concentrations. All three porphyrins at concentrations greater than 10 microM exhibited a significant toxicity toward the cysts, in particular lowering the degree of excystment. Upon visible light irradiation of the porphyrin-loaded cysts, extensive photodamage was observed even in the presence of 1 microM porphyrin, as shown by light microscopy observations and counting of vegetative emerging cells The presence of one decyl or tetradecyl hydrocarbon chain caused about 10-fold enhancement of the phototoxic effects.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Porphyrins
/
Photosensitizing Agents
/
Eukaryota
Limits:
Animals
Language:
En
Journal:
Photochem Photobiol Sci
Journal subject:
BIOLOGIA
/
QUIMICA
Year:
2002
Document type:
Article
Affiliation country:
Egypt