Threshold for carcinogenicity of N-nitrosodiethylamine for esophageal tumors in rats.
Food Chem Toxicol
; 41(5): 739-41, 2003 May.
Article
in En
| MEDLINE
| ID: mdl-12659727
ABSTRACT
In a study on 4080 rats by Peto et al. [Cancer Res. 51 (1991) 6415], esophageal neoplasms induced by N-nitrosodiethylamine (NDEA) were the tumors most clearly demonstrated to have a dose response from administration of the compound to male rats. However, they were unable to predict the shape of the dose-response curve at low doses. These data were reanalyzed in the present study for dose response on a logarithmic scale for dose. In contrast to the conclusion of Peto et al., the reanalysis shows a convincingly sharp threshold at 10(17.1) molecules/kg/day. This unequivocal threshold has substantial implications for risk assessment of chemical carcinogens.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Esophageal Neoplasms
/
Carcinogens
/
Diethylnitrosamine
/
Alkylating Agents
Type of study:
Etiology_studies
/
Prognostic_studies
Limits:
Animals
Language:
En
Journal:
Food Chem Toxicol
Year:
2003
Document type:
Article
Affiliation country:
United States