Intercellular calcium communication regulates platelet aggregation and thrombus growth.
J Cell Biol
; 160(7): 1151-61, 2003 Mar 31.
Article
in En
| MEDLINE
| ID: mdl-12668663
ABSTRACT
The ability of platelets to form stable adhesion contacts with other activated platelets (platelet cohesion or aggregation) at sites of vascular injury is essential for hemostasis and thrombosis. In this study, we have examined the mechanisms regulating cytosolic calcium flux during the development of platelet-platelet adhesion contacts under the influence of flow. An examination of platelet calcium flux during platelet aggregate formation in vitro demonstrated a key role for intercellular calcium communication (ICC) in regulating the recruitment of translocating platelets into developing aggregates. We demonstrate that ICC is primarily mediated by a signaling mechanism operating between integrin alpha IIb beta 3 and the recently cloned ADP purinergic receptor P2Y12. Furthermore, we demonstrate that the efficiency by which calcium signals are propagated within platelet aggregates plays an important role in dictating the rate and extent of thrombus growth.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Thrombosis
/
Blood Platelets
/
Cell Communication
/
Platelet Aggregation
/
Calcium
/
Receptors, Purinergic P2
/
Platelet Glycoprotein GPIIb-IIIa Complex
Type of study:
Prognostic_studies
Limits:
Humans
Language:
En
Journal:
J Cell Biol
Year:
2003
Document type:
Article
Affiliation country:
Australia