Treatment of advanced mycosis fungoides by allogeneic stem-cell transplantation with a nonmyeloablative regimen.
Bone Marrow Transplant
; 31(8): 663-6, 2003 Apr.
Article
in En
| MEDLINE
| ID: mdl-12692606
ABSTRACT
SUMMARY:
Given the poor prognosis of patients with advanced cutaneous T-cell lymphoma and the high transplant-related mortality associated with conventional allogeneic bone marrow transplantation, we performed nonmyeloablative transplantation of allogeneic stem cells (ASCT) from HLA-identical siblings in three patients with this disease. All patients achieved full donor engraftment, clearance of clonal T cells leading to durable complete remissions but experienced high incidence of infections, which proved fatal in one case. These results suggest that nonmyeloablative ASCT is a novel and potentially curative therapy for patients with advanced T-cell lymphomas who have a histocompatible sibling.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Lymphoma, T-Cell, Cutaneous
/
Mycosis Fungoides
/
Stem Cell Transplantation
/
Antifungal Agents
Type of study:
Prognostic_studies
Limits:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Bone Marrow Transplant
Journal subject:
TRANSPLANTE
Year:
2003
Document type:
Article
Affiliation country:
Italy