Synthesis and biological evaluation of N-heterocyclic indolyl glyoxylamides as orally active anticancer agents.

Li, Wen-Tai; Hwang, Der-Ren; Chen, Ching-Ping; Shen, Chien-Wei; Huang, Chen-Long; Chen, Tung-Wei; Lin, Chi-Hung; Chang, Yee-Ling; Chang, Ying-Ying; Lo, Yue-Kan; Tseng, Huan-Yi; Lin, Chu-Chung; Song, Jeng-Shin; Chen, Hua-Chien; Chen, Shu-Jen; Wu, Se-Hui; Chen, Chiung-Tong

Li, Wen-Tai; Hwang, Der-Ren; Chen, Ching-Ping; Shen, Chien-Wei; Huang, Chen-Long; Chen, Tung-Wei; Lin, Chi-Hung; Chang, Yee-Ling; Chang, Ying-Ying; Lo, Yue-Kan; Tseng, Huan-Yi; Lin, Chu-Chung; Song, Jeng-Shin; Chen, Hua-Chien; Chen, Shu-Jen; Wu, Se-Hui; Chen, Chiung-Tong.

Affiliation

Li WT; Division of Biotechnology and Pharmaceutical Research, National Health Research Institutes, 9F, 161, Sec. 6, Min-Chiuan East Road, Nei-Hu, Taipei 114, Taiwan, ROC.

J Med Chem ; 46(9): 1706-15, 2003 Apr 24.

Article in En | MEDLINE | ID: mdl-12699388

Subject(s)

Antineoplastic Agents/chemical synthesis; Glyoxylates/chemical synthesis; Indoles/chemical synthesis; Thiazoles/chemical synthesis; Administration, Oral; Animals; Antineoplastic Agents/chemistry; Antineoplastic Agents/pharmacology; Apoptosis; Cell Division/drug effects; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Female; Glyoxylates/chemistry; Glyoxylates/pharmacology; Humans; Indoles/chemistry; Indoles/pharmacology; Leukemia P388/mortality; Mice; Mice, Inbred DBA; Neoplasm Transplantation; Structure-Activity Relationship; Thiazoles/chemistry; Thiazoles/pharmacology; Tumor Cells, Cultured

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Collection: 01-internacional Database: MEDLINE Main subject: Thiazoles / Glyoxylates / Indoles / Antineoplastic Agents Limits: Animals / Female / Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2003 Document type: Article Country of publication: United States

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