Drug Evaluation, Preclinical/methods; Two-Hybrid System Techniques; Adaptor Proteins, Signal Transducing; Animals; Cell Line; Chloramphenicol O-Acetyltransferase/analysis; Chloramphenicol O-Acetyltransferase/genetics; Chlorocebus aethiops; DNA, Complementary/genetics; DNA-Binding Proteins/genetics; DNA-Binding Proteins/metabolism; Fibroblasts; Genes, Reporter; Herpes Simplex Virus Protein Vmw65/genetics; Herpes Simplex Virus Protein Vmw65/metabolism; Ligands; Luciferases/analysis; Luciferases/genetics; Mammals; Nuclear Proteins/genetics; Nuclear Proteins/metabolism; Nuclear Receptor Interacting Protein 1; Protein Binding; Protein Conformation; Protein Structure, Tertiary; Recombinant Fusion Proteins/genetics; Recombinant Fusion Proteins/metabolism; Saccharomyces cerevisiae Proteins/genetics; Saccharomyces cerevisiae Proteins/metabolism; Structure-Activity Relationship; Transcription Factors/genetics; Transcription Factors/metabolism