N(2)-substituted D,L-cycloserine derivatives: synthesis and evaluation as alanine racemase inhibitors.
J Antibiot (Tokyo)
; 56(2): 160-8, 2003 Feb.
Article
in En
| MEDLINE
| ID: mdl-12715876
ABSTRACT
A select series of N(2)-substituted D,L-cycloserine derivatives were prepared a ndevaluated for inhibitory activity against purified alanine racemases (alr gene product) from Escherichia coli, Staphylococcus aureus, and Mycobacterium tuberculosis, as well as in a growth inhibition assay. N(2)-Modification led to loss of enzymatic inhibitory activity in most cases consistent with a recent proposal for cycloserine function.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Cycloserine
/
Alanine Racemase
/
Enzyme Inhibitors
/
Antibiotics, Antitubercular
Language:
En
Journal:
J Antibiot (Tokyo)
Year:
2003
Document type:
Article
Affiliation country:
United States