Synthesis and biological activity of novel 5-(omega-aryloxyalkyl)oxazole derivatives as brain-derived neurotrophic factor inducers.

Maekawa, Tsuyoshi; Sakai, Nozomu; Tawada, Hiroyuki; Murase, Katsuhito; Hazama, Masatoshi; Sugiyama, Yasuo; Momose, Yu

Maekawa, Tsuyoshi; Sakai, Nozomu; Tawada, Hiroyuki; Murase, Katsuhito; Hazama, Masatoshi; Sugiyama, Yasuo; Momose, Yu.

Affiliation

Maekawa T; Medicinal Chemistry Research Laboratories II, Pharmaceutical Research Division, Takeda Chemical Industries, Ltd., Osaka, Japan. Maekawa_Tsuyoshi@takeda.co.jp

Chem Pharm Bull (Tokyo) ; 51(5): 565-73, 2003 May.

Article in En | MEDLINE | ID: mdl-12736457

Subject(s)

Alkanes/chemical synthesis; Brain Chemistry/drug effects; Brain-Derived Neurotrophic Factor/biosynthesis; Oxazoles/chemical synthesis; Alkanes/pharmacology; Animals; Blood Glucose/metabolism; Body Weight/drug effects; Brain Neoplasms/metabolism; Cell Line, Tumor; Diabetes Mellitus, Experimental/complications; Diabetic Neuropathies/drug therapy; Humans; Indicators and Reagents; Magnetic Resonance Spectroscopy; Male; Neural Conduction/drug effects; Neuroblastoma/metabolism; Oxazoles/pharmacology; Rats; Rats, Sprague-Dawley; Reaction Time/drug effects; Stimulation, Chemical; Structure-Activity Relationship; Subcellular Fractions/chemistry

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Collection: 01-internacional Database: MEDLINE Main subject: Oxazoles / Brain Chemistry / Brain-Derived Neurotrophic Factor / Alkanes Limits: Animals / Humans / Male Language: En Journal: Chem Pharm Bull (Tokyo) Year: 2003 Document type: Article Affiliation country: Japan Country of publication: Japan

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