Chronic hyperglycemia impairs insulin secretion by affecting insulin receptor expression, splicing, and signaling in RIN beta cell line and human islets of Langerhans.

Hribal, Marta L; Perego, Lucia; Lovari, Sarah; Andreozzi, Francesco; Menghini, Rossella; Perego, Carla; Finzi, Giovanna; Usellini, Luciana; Placidi, Claudia; Capella, Carlo; Guzzi, Valeria; Lauro, Davide; Bertuzzi, Federico; Davalli, Alberto; Pozza, Guido; Pontiroli, Antonio; Federici, Massimo; Lauro, Renato; Brunetti, Antonio; Folli, Franco; Sesti, Giorgio

Hribal, Marta L; Perego, Lucia; Lovari, Sarah; Andreozzi, Francesco; Menghini, Rossella; Perego, Carla; Finzi, Giovanna; Usellini, Luciana; Placidi, Claudia; Capella, Carlo; Guzzi, Valeria; Lauro, Davide; Bertuzzi, Federico; Davalli, Alberto; Pozza, Guido; Pontiroli, Antonio; Federici, Massimo; Lauro, Renato; Brunetti, Antonio; Folli, Franco; Sesti, Giorgio.

Affiliation

Hribal ML; Laboratory of Molecular Medicine, Department of Internal Medicine, University of Rome-Tor Vergata, Rome, Italy.

FASEB J ; 17(10): 1340-2, 2003 Jul.

Article in En | MEDLINE | ID: mdl-12738810

Subject(s)

Glucose/pharmacology; Insulin/metabolism; Islets of Langerhans/metabolism; Protein Serine-Threonine Kinases; Receptor, Insulin/genetics; Signal Transduction; Adaptor Proteins, Signal Transducing; Carrier Proteins/metabolism; Cell Cycle Proteins; Cell Line; HMGA1a Protein/metabolism; Humans; Insulin/biosynthesis; Insulin Receptor Substrate Proteins; Insulin Secretion; Intracellular Signaling Peptides and Proteins; Islets of Langerhans/drug effects; Models, Biological; Pancreas/chemistry; Pancreas/ultrastructure; Phosphatidylinositol 3-Kinases/metabolism; Phosphoproteins/metabolism; Protein Isoforms/genetics; Protein Isoforms/metabolism; Proto-Oncogene Proteins/metabolism; Proto-Oncogene Proteins c-akt; RNA Splicing; Receptor, Insulin/analysis; Receptor, Insulin/metabolism; Ribosomal Protein S6 Kinases, 70-kDa/metabolism; Transcription, Genetic

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Collection: 01-internacional Database: MEDLINE Main subject: Receptor, Insulin / Signal Transduction / Islets of Langerhans / Protein Serine-Threonine Kinases / Glucose / Insulin Type of study: Prognostic_studies Limits: Humans Language: En Journal: FASEB J Journal subject: BIOLOGIA / FISIOLOGIA Year: 2003 Document type: Article Affiliation country: Italy

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