Ionic states of substrates and transition state analogues at the catalytic sites of N-ribosyltransferases.

Sauve, Anthony A; Cahill, Sean M; Zech, Stephan G; Basso, Luiz A; Lewandowicz, Andrzej; Santos, Diogenes S; Grubmeyer, Charles; Evans, Gary B; Furneaux, Richard H; Tyler, Peter C; McDermott, Ann; Girvin, Mark E; Schramm, Vern L

Sauve, Anthony A; Cahill, Sean M; Zech, Stephan G; Basso, Luiz A; Lewandowicz, Andrzej; Santos, Diogenes S; Grubmeyer, Charles; Evans, Gary B; Furneaux, Richard H; Tyler, Peter C; McDermott, Ann; Girvin, Mark E; Schramm, Vern L.

Affiliation

Sauve AA; Department of Biochemistry, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA.

Biochemistry ; 42(19): 5694-705, 2003 May 20.

Article in En | MEDLINE | ID: mdl-12741826

Subject(s)

Hypoxanthine Phosphoribosyltransferase/chemistry; Hypoxanthine Phosphoribosyltransferase/metabolism; Purine-Nucleoside Phosphorylase/chemistry; Purine-Nucleoside Phosphorylase/metabolism; Catalytic Domain; Guanosine/chemistry; Guanosine/metabolism; Guanosine Monophosphate/chemistry; Guanosine Monophosphate/metabolism; Humans; Hydrogen-Ion Concentration; Hypoxanthine Phosphoribosyltransferase/genetics; In Vitro Techniques; Ions/chemistry; Kinetics; Molecular Structure; Mycobacterium tuberculosis/enzymology; Mycobacterium tuberculosis/genetics; Nuclear Magnetic Resonance, Biomolecular; Phosphorylation; Purine Nucleosides; Purine-Nucleoside Phosphorylase/genetics; Pyrimidinones/chemistry; Pyrimidinones/metabolism; Pyrroles/chemistry; Pyrroles/metabolism; Recombinant Proteins/chemistry; Recombinant Proteins/genetics; Recombinant Proteins/metabolism; Substrate Specificity

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Collection: 01-internacional Database: MEDLINE Main subject: Purine-Nucleoside Phosphorylase / Hypoxanthine Phosphoribosyltransferase Limits: Humans Language: En Journal: Biochemistry Year: 2003 Document type: Article Affiliation country: United States

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