Serine 776 of ataxin-1 is critical for polyglutamine-induced disease in SCA1 transgenic mice.

Emamian, Effat S; Kaytor, Michael D; Duvick, Lisa A; Zu, Tao; Tousey, Susan K; Zoghbi, Huda Y; Clark, H Brent; Orr, Harry T

Emamian, Effat S; Kaytor, Michael D; Duvick, Lisa A; Zu, Tao; Tousey, Susan K; Zoghbi, Huda Y; Clark, H Brent; Orr, Harry T.

Affiliation

Emamian ES; Department of Laboratory Medicine and Pathology, University of Minnesota, Mayo Mail Code 206, Minneapolis, MN 55455, USA.

Neuron ; 38(3): 375-87, 2003 May 08.

Article in En | MEDLINE | ID: mdl-12741986

Subject(s)

Cell Nucleus/metabolism; Nerve Tissue Proteins/metabolism; Nuclear Proteins/metabolism; Peptides/metabolism; Purkinje Cells/metabolism; Serine/metabolism; Spinocerebellar Ataxias/genetics; Spinocerebellar Ataxias/metabolism; Amino Acid Sequence/genetics; Animals; Ataxin-1; Ataxins; CHO Cells; COS Cells; Cell Nucleus/genetics; Cell Nucleus/pathology; Cricetinae; Disease Models, Animal; Female; Inclusion Bodies/genetics; Inclusion Bodies/metabolism; Inclusion Bodies/pathology; Male; Mice; Mice, Transgenic; Mutation/genetics; Nerve Tissue Proteins/genetics; Nuclear Proteins/genetics; Peptides/genetics; Phenotype; Purkinje Cells/pathology; Serine/genetics; Spinocerebellar Ataxias/physiopathology; Trinucleotide Repeat Expansion/genetics

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Collection: 01-internacional Database: MEDLINE Main subject: Peptides / Purkinje Cells / Serine / Nuclear Proteins / Cell Nucleus / Spinocerebellar Ataxias / Nerve Tissue Proteins Limits: Animals Language: En Journal: Neuron Journal subject: NEUROLOGIA Year: 2003 Document type: Article Affiliation country: United States Country of publication: United States

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