Deactivation of ROCK-II by Y-27632 enhances basolateral pancreatic enzyme secretion and acute pancreatitis induced by CCK analogues.

Kusama, Kazushige; Nozu, Fumihiko; Awai, Toshinari; Tanaka, Shigeki; Honma, Ikuo; Tsunoda, Yasuhiro; Mitamura, Keiji

Kusama, Kazushige; Nozu, Fumihiko; Awai, Toshinari; Tanaka, Shigeki; Honma, Ikuo; Tsunoda, Yasuhiro; Mitamura, Keiji.

Affiliation

Kusama K; Second Department of Internal Medicine, Showa University School of Medicine, 1-5-8 Hatanodai Shinagawa-ku, 142-8666, Tokyo, Japan.

Biochem Biophys Res Commun ; 305(2): 339-44, 2003 May 30.

Article in En | MEDLINE | ID: mdl-12745080

Subject(s)

Amides/pharmacology; Amylases/metabolism; Enzyme Inhibitors/pharmacology; Pancreas/enzymology; Pancreatitis/enzymology; Protein Serine-Threonine Kinases/antagonists & inhibitors; Pyridines/pharmacology; Acute Disease; Animals; Cell Polarity; Cells, Cultured; Ceruletide; Intracellular Signaling Peptides and Proteins; Male; Mice; Pancreas/metabolism; Pancreas/pathology; Pancreatitis/chemically induced; Pancreatitis/pathology; Protein Serine-Threonine Kinases/metabolism; Protein Serine-Threonine Kinases/physiology; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; rhoA GTP-Binding Protein/metabolism; rhoA GTP-Binding Protein/physiology

Search on Google

Add to My VHL

XML

PubMed Links

Collection: 01-internacional Database: MEDLINE Main subject: Pancreas / Pancreatitis / Pyridines / Protein Serine-Threonine Kinases / Enzyme Inhibitors / Amides / Amylases Limits: Animals Language: En Journal: Biochem Biophys Res Commun Year: 2003 Document type: Article Affiliation country: Japan Country of publication: United States

Search on Google

Add to My VHL

XML

PubMed Links