Chemokine receptor CCR2 is not essential for the development of experimental cerebral malaria.
Infect Immun
; 71(6): 3648-51, 2003 Jun.
Article
in En
| MEDLINE
| ID: mdl-12761155
ABSTRACT
Infection with Plasmodium berghei ANKA induces cerebral malaria in susceptible mice. Brain-sequestered CD8(+) T cells are responsible for this pathology. We have evaluated the role of CCR2, a chemokine receptor expressed on CD8(+) T cells. Infected CCR2-deficient mice were as susceptible to cerebral malaria as wild-type mice were, and CD8(+) T-cell migration to the brain was not abolished.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Malaria, Cerebral
/
Receptors, Chemokine
Limits:
Animals
Language:
En
Journal:
Infect Immun
Year:
2003
Document type:
Article
Affiliation country:
France