Selective COX-2 inhibition is associated with decreased mucosal damage induced by acid and pepsin in rabbit esophagitis.

Lanas, Angel; Jiménez, Pilar; Ferrández, Angel; Escartín, Alfredo; Arenas, Juan; Esteva, Francisco; Ortego, Javier

Lanas, Angel; Jiménez, Pilar; Ferrández, Angel; Escartín, Alfredo; Arenas, Juan; Esteva, Francisco; Ortego, Javier.

Affiliation

Lanas A; Service of Digestive Diseases, Unit of Gastrointestinal Research, University Hospital, Unidad Mixta de Investigación, Zaragoza, Spain.

Inflammation ; 27(1): 21-9, 2003 Feb.

Article in En | MEDLINE | ID: mdl-12772774

Subject(s)

Cyclooxygenase Inhibitors/pharmacology; Esophagitis/drug therapy; Isoenzymes/metabolism; Mouth Mucosa/drug effects; Prostaglandin-Endoperoxide Synthases/metabolism; Acids/administration & dosage; Acids/pharmacology; Animals; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors/administration & dosage; Esophagitis/chemically induced; Esophagitis/enzymology; Furans/administration & dosage; Furans/pharmacology; Indomethacin/administration & dosage; Indomethacin/pharmacology; Mouth Mucosa/enzymology; Mouth Mucosa/pathology; Pepsin A/administration & dosage; Pepsin A/pharmacology; Piroxicam/administration & dosage; Piroxicam/pharmacology; Prostaglandins/analysis; Rabbits

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Collection: 01-internacional Database: MEDLINE Main subject: Cyclooxygenase Inhibitors / Prostaglandin-Endoperoxide Synthases / Esophagitis / Isoenzymes / Mouth Mucosa Type of study: Risk_factors_studies Limits: Animals Language: En Journal: Inflammation Year: 2003 Document type: Article Affiliation country: Spain Country of publication: United States

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