Gamma-tubulins and their functions.

ABSTRACT

gamma-Tubulin is a ubiquitous phylogenetically conserved member of tubulin superfamily. In comparison with alpha beta-tubulin dimers, it is a low abundance protein present within the cells in both various types of microtubule-organizing centers and cytoplasmic protein complexes. gamma-Tubulin small complexes are subunits of the gamma-tubulin ring complex, which is involved in microtubule nucleation and capping of the minus ends of microtubules. In the past years important findings have advanced the understanding of the structure and function of gamma-tubulin ring complexes. Recent evidences suggest that the functions of gamma-tubulin extend beyond microtubule nucleation.