Identification of epitopes on cytochrome P450 3A4/5 recognized by monoclonal antibodies.

Parimoo, Bhama; Mishin, Vladimir M; Busch, Christine M; Thomas, Paul E

Parimoo, Bhama; Mishin, Vladimir M; Busch, Christine M; Thomas, Paul E.

Affiliation

Parimoo B; Chemical Biology Department, Ernest Mario School of Pharmacy, Rutgers The State University of New Jersey, EOHSI Bldg., 170 Frelinghuysen Road, Piscataway, NJ 08854-8020, USA.

Arch Biochem Biophys ; 414(2): 244-54, 2003 Jun 15.

Article in En | MEDLINE | ID: mdl-12781776

Subject(s)

Antibodies, Monoclonal/metabolism; Cytochrome P-450 Enzyme System/chemistry; Quinidine/analogs & derivatives; Animals; Baculoviridae/metabolism; Blotting, Western; Cytochrome P-450 CYP3A; DNA, Complementary/metabolism; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Epitopes; Escherichia coli/metabolism; Glutathione Transferase/metabolism; Humans; Immunoglobulin G/metabolism; Mice; Mice, Inbred BALB C; Microsomes, Liver/metabolism; Models, Genetic; Plasmids/metabolism; Polymerase Chain Reaction; Protein Conformation; Protein Structure, Tertiary; Quinidine/metabolism; Recombinant Fusion Proteins/metabolism; Sequence Analysis, DNA

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Collection: 01-internacional Database: MEDLINE Main subject: Quinidine / Cytochrome P-450 Enzyme System / Antibodies, Monoclonal Type of study: Diagnostic_studies Limits: Animals / Humans Language: En Journal: Arch Biochem Biophys Year: 2003 Document type: Article Affiliation country: United States Country of publication: United States

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