Reactive oxygen species induce swelling and cytochrome c release but not transmembrane depolarization in isolated rat brain mitochondria.

Galindo, María F; Jordán, Joaquín; González-García, Carmen; Ceña, Valentín

Galindo, María F; Jordán, Joaquín; González-García, Carmen; Ceña, Valentín.

Affiliation

Galindo MF; Centro Regional de Investigaciones Biomédicas, Universidad de Castilla-La Mancha, Avda. España s/n, Albacete 02071, Spain.

Br J Pharmacol ; 139(4): 797-804, 2003 Jun.

Article in En | MEDLINE | ID: mdl-12813003

Subject(s)

Cytochromes c/metabolism; Membrane Potentials/physiology; Mitochondrial Swelling/drug effects; Reactive Oxygen Species/metabolism; Action Potentials/drug effects; Animals; Apoptosis; Brain/cytology; Calcium/metabolism; Calcium/pharmacokinetics; Caspases/biosynthesis; Caspases/metabolism; Cytochromes c/drug effects; Ion Channels/drug effects; Ion Channels/physiology; Mitochondria/metabolism; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Mitochondrial Swelling/physiology; NADP/analysis; NADP/metabolism; Oxides/pharmacokinetics; Oxygen Consumption/physiology; Potassium Compounds/pharmacokinetics; Rats; Rats, Sprague-Dawley; Superoxides/pharmacokinetics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Reactive Oxygen Species / Cytochromes c / Membrane Potentials / Mitochondrial Swelling Limits: Animals Language: En Journal: Br J Pharmacol Year: 2003 Document type: Article Affiliation country: Spain

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