Novel IKK inhibitors: beta-carbolines.

Castro, Alfredo C; Dang, Luan C; Soucy, François; Grenier, Louis; Mazdiyasni, Hormoz; Hottelet, Maria; Parent, Lana; Pien, Christine; Palombella, Vito; Adams, Julian

Castro, Alfredo C; Dang, Luan C; Soucy, François; Grenier, Louis; Mazdiyasni, Hormoz; Hottelet, Maria; Parent, Lana; Pien, Christine; Palombella, Vito; Adams, Julian.

Affiliation

Castro AC; Millennium Pharmaceuticals Inc., 35 Landsdowne Street, 02139, Cambridge, MA, USA.

Bioorg Med Chem Lett ; 13(14): 2419-22, 2003 Jul 21.

Article in En | MEDLINE | ID: mdl-12824047

Subject(s)

Carbolines/chemical synthesis; Carbolines/pharmacology; Enzyme Inhibitors/chemical synthesis; Enzyme Inhibitors/pharmacology; Protein Serine-Threonine Kinases/antagonists & inhibitors; Blotting, Western; Electrophoretic Mobility Shift Assay; HeLa Cells; Humans; I-kappa B Kinase; Precipitin Tests; Structure-Activity Relationship

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Collection: 01-internacional Database: MEDLINE Main subject: Carbolines / Protein Serine-Threonine Kinases / Enzyme Inhibitors Limits: Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2003 Document type: Article Affiliation country: United States Country of publication: United kingdom

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