Perifusion model for detoxification of drugs in a bioartificial liver.
Int J Artif Organs
; 26(5): 383-94, 2003 May.
Article
in En
| MEDLINE
| ID: mdl-12828304
ABSTRACT
Detoxification of a drug in a bioartificial liver (BAL) during an in vitro experiment was theoretically carried out based on a perifusion model. The detoxification capacity assay, the rates of disappearance of the chemicals such as flow-limited and enzyme-limited drugs in the BAL system could be defined from models of hepatic perfusion-elimination relationships. When the flow-limited drug administrated under a quasi-equilibrium condition, a two-compartment model for the concentration behavior of the drug was introduced and compared with a one-compartment model. For both models, equations involving hepatic drug clearance and various pharmacokinetic parameters were derived under initial bolus loading and constant-rate infusion plus bolus loading conditions. The concentration of enzyme-limited drug in the BAL decreased linearly with time in contrast with the concentration profile of the flow-limited drug followed by exponential functions. The perifusion model offers a quantitative understanding of the elimination kinetics of chemicals such as flow-limited and enzyme-limited drugs in a bioartificial liver and a comparison between the BAL and human liver.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Inactivation, Metabolic
/
Liver, Artificial
/
Models, Biological
Limits:
Humans
Language:
En
Journal:
Int J Artif Organs
Year:
2003
Document type:
Article