CXCR4 regulates interneuron migration in the developing neocortex.
J Neurosci
; 23(12): 5123-30, 2003 Jun 15.
Article
in En
| MEDLINE
| ID: mdl-12832536
ABSTRACT
The chemotactic factors directing interneuron migration during cerebrocortical development are essentially unknown. Here we identify the CXC chemokine receptor 4 (CXCR4) in interneuron precursors migrating from the basal forebrain to the neocortex and demonstrate that stromal cell-derived factor-1 (SDF-1) is a potent chemoattractant for isolated striatal precursors. In addition, we show that CXCR4 is present in early generated Cajal-Retzius cells of the cortical marginal zone. In mice with a null mutation in CXCR4 or SDF-1, interneurons were severely underrepresented in the superficial layers and ectopically placed in the deep layers of the neocortex. In contrast, the submeningeal positioning of Cajal-Retzius cells was unaffected. Thus, our findings suggest that SDF-1, which is highly expressed in the embryonic leptomeninx, selectively regulates migration and layer-specific integration of CXCR4-expressing interneurons during neocortical development.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Cell Movement
/
Neocortex
/
Receptors, CXCR4
/
Interneurons
Type of study:
Prognostic_studies
Language:
En
Journal:
J Neurosci
Year:
2003
Document type:
Article
Affiliation country:
Germany