Function and regulation of Ena/VASP proteins.

Kwiatkowski, Adam V; Gertler, Frank B; Loureiro, Joseph J

Kwiatkowski, Adam V; Gertler, Frank B; Loureiro, Joseph J.

Affiliation

Kwiatkowski AV; Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

Trends Cell Biol ; 13(7): 386-92, 2003 Jul.

Article in En | MEDLINE | ID: mdl-12837609

ABSTRACT

ABSTRACT

Regulation of cytoskeletal dynamics is required to coordinate cell movement, adhesion and shape change. The Ena/VASP protein family is thought to play an important role in linking signaling pathways to remodeling of the actin cytoskeleton. This review will examine the mechanisms by which Ena/VASP function might control actin dynamics and how these proteins are linked to various signaling pathways.

Subject(s)

Actin Cytoskeleton/metabolism; Cell Adhesion Molecules/metabolism; Cell Adhesion/physiology; Cell Movement/physiology; DNA-Binding Proteins/metabolism; Eukaryotic Cells/metabolism; Phosphoproteins/metabolism; Animals; Cell Size/physiology; Eukaryotic Cells/ultrastructure; Humans; Microfilament Proteins; Pseudopodia/metabolism; Pseudopodia/ultrastructure

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Collection: 01-internacional Database: MEDLINE Main subject: Phosphoproteins / Actin Cytoskeleton / Cell Adhesion Molecules / Cell Adhesion / Cell Movement / DNA-Binding Proteins / Eukaryotic Cells Limits: Animals / Humans Language: En Journal: Trends Cell Biol Year: 2003 Document type: Article Affiliation country: United States

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