Recombinant human G-CSF and retinoic acid in synergistically inducing granulocyte differentiation of human promyelocytic leukemic cells.
Chin Med J (Engl)
; 105(9): 707-12, 1992 Sep.
Article
in En
| MEDLINE
| ID: mdl-1283843
ABSTRACT
The effects of recombinant human G-CSF (rhG-CSF) and retinoic acid (RA) were studied on the proliferation and differentiation of HL-60 cells and human acute myeloid leukemic cells. Synergistic effect on granulocyte differentiation was observed when HL-60 cells and primary acute promyelocytic leukemic cells were cocultured with RA plus rhG-CSF. rhG-CSF combined with RA increased more significantly the percentage of mature cells than RA alone and greatly increased NBT reduction activity (P < 0.001). These results suggested that proliferated effect of rhG-CSF on leukemic cells may be important for inducing differentiation of myeloid leukemic cells. But this effect might expose the patients to the risk of acute myeloblastic leukemia if G-CSF was used alone. However, RA could not only rule out the latter situation but retain former merit as well. The authors suggest that the combined use of G-CSF with RA is probably a new approach to the treatment of leukemia.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Tretinoin
/
Leukemia, Promyelocytic, Acute
/
Granulocyte Colony-Stimulating Factor
Limits:
Humans
Language:
En
Journal:
Chin Med J (Engl)
Year:
1992
Document type:
Article
Country of publication:
CHINA
/
CN
/
REPUBLIC OF CHINA