Epoxyeicosatrienoic acids activate transglutaminases in situ and induce cornification of epidermal keratinocytes.

Ladd, Patricia A; Du, Liping; Capdevila, Jorge H; Mernaugh, Raymond; Keeney, Diane S

Ladd, Patricia A; Du, Liping; Capdevila, Jorge H; Mernaugh, Raymond; Keeney, Diane S.

Affiliation

Ladd PA; Department of Medicine, Division of Dermatology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA.

J Biol Chem ; 278(37): 35184-92, 2003 Sep 12.

Article in En | MEDLINE | ID: mdl-12840027

Subject(s)

8,11,14-Eicosatrienoic Acid/analogs & derivatives; 8,11,14-Eicosatrienoic Acid/pharmacology; Aryl Hydrocarbon Hydroxylases/metabolism; Keratinocytes/physiology; Mixed Function Oxygenases/metabolism; Transglutaminases/metabolism; Adenoviridae/genetics; Amino Acid Sequence; Animals; Biotinylation; Cadaverine/analogs & derivatives; Cadaverine/pharmacology; Cell Differentiation/drug effects; Cells, Cultured; Cytochrome P450 Family 2; Enzyme Activation/drug effects; Genetic Vectors; Humans; Keratinocytes/cytology; Keratinocytes/drug effects; Mice; Molecular Sequence Data; Peptide Fragments/chemistry; Protein Precursors/chemistry; Protein Precursors/metabolism; Skin/metabolism; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Substrate Specificity

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Collection: 01-internacional Database: MEDLINE Main subject: Aryl Hydrocarbon Hydroxylases / Keratinocytes / Transglutaminases / 8,11,14-Eicosatrienoic Acid / Mixed Function Oxygenases Limits: Animals / Humans Language: En Journal: J Biol Chem Year: 2003 Document type: Article Affiliation country: United States Country of publication: United States

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