Expression, desensitization, and internalization of the ACTH receptor (MC2R).
Ann N Y Acad Sci
; 994: 111-7, 2003 Jun.
Article
in En
| MEDLINE
| ID: mdl-12851305
ABSTRACT
Research into the functions and mechanisms of action of the melanocortin 2 receptor (MC2R) has been severely hampered by difficulties in expressing this gene in heterologous cells. This probably arises because of the need for a cofactor for cell surface expression. Using either the Y1 cell line that expresses endogenous MC2R or the Y6 cell line that expresses this putative expression factor, we have explored the mechanisms of desensitization and internalization after agonist stimulation. Protein kinase A dependence of desensitization has been demonstrated, although internalization is apparently independent of this kinase and dependent on a G protein receptor kinase. Possible underlying reasons for this paradox are discussed.
Search on Google
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Receptors, Corticotropin
Limits:
Animals
/
Humans
Language:
En
Journal:
Ann N Y Acad Sci
Year:
2003
Document type:
Article
Affiliation country:
United kingdom
Publication country:
EEUU
/
ESTADOS UNIDOS
/
ESTADOS UNIDOS DA AMERICA
/
EUA
/
UNITED STATES
/
UNITED STATES OF AMERICA
/
US
/
USA