Assessment of disease activity in inflammatory bowel disease; relevance for clinical trials.
Neth J Med
; 61(4): 105-10, 2003 Apr.
Article
in En
| MEDLINE
| ID: mdl-12852718
ABSTRACT
In patients with inflammatory bowel disease, assessment of disease activity is important in order to monitor and adjust therapy. In individual patients, disease evaluation is largely based on subjective symptoms. However, for disease evaluation in clinical trials, an objective and reproducible disease activity index is needed. At present, a number of activity indices are available for Crohn's disease and for ulcerative colitis. These indices may be distinguished in more subjective clinical indices, more objective endoscopic and histological indices, and in indices with combinations of both subjective and objective parameters. In the design of a new clinical trial, an appropriate disease activity index should be selected which is based on the patient selection criteria and the aims of the study.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Severity of Illness Index
/
Colitis, Ulcerative
/
Crohn Disease
Limits:
Humans
Language:
En
Journal:
Neth J Med
Year:
2003
Document type:
Article
Publication country:
HOLANDA
/
HOLLAND
/
NETHERLANDS
/
NL
/
PAISES BAJOS
/
THE NETHERLANDS