Granulocyte-macrophage colony-stimulating factor and interleukin-3 induce cell cycle progression through the synthesis of c-Myc protein by internal ribosome entry site-mediated translation via phosphatidylinositol 3-kinase pathway in human factor-dependent leukemic cells.

Kobayashi, Norihiko; Saeki, Kumiko; Yuo, Akira

Kobayashi, Norihiko; Saeki, Kumiko; Yuo, Akira.

Affiliation

Kobayashi N; Department of Hematology, Research Institute, International Medical Center of Japan, 1-21-1 Toyama, Shinjuku-ku, Tokyo 162-8655, Japan.

Blood ; 102(9): 3186-95, 2003 Nov 01.

Article in En | MEDLINE | ID: mdl-12855588

Subject(s)

Cell Cycle/drug effects; Granulocyte-Macrophage Colony-Stimulating Factor/physiology; Interleukin-3/physiology; Leukemia/pathology; Phosphatidylinositol 3-Kinases/metabolism; Protein Biosynthesis/drug effects; Proto-Oncogene Proteins c-myc/biosynthesis; Cell Line, Tumor; Granulocyte-Macrophage Colony-Stimulating Factor/pharmacology; Growth Substances/pharmacology; Humans; Interleukin-3/pharmacology; Peptide Chain Initiation, Translational/drug effects; RNA, Messenger/biosynthesis; Ribosomes; Signal Transduction; Up-Regulation/drug effects

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Collection: 01-internacional Database: MEDLINE Main subject: Protein Biosynthesis / Leukemia / Cell Cycle / Granulocyte-Macrophage Colony-Stimulating Factor / Proto-Oncogene Proteins c-myc / Interleukin-3 / Phosphatidylinositol 3-Kinases Limits: Humans Language: En Journal: Blood Year: 2003 Document type: Article Affiliation country: Japan Country of publication: United States

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