Variations in Prkdc and susceptibility to benzene-induced toxicity in mice.

Faiola, Brenda; Bauer, Alison K; Fuller, Elizabeth S; Wong, Victoria A; Pluta, Linda J; Abernethy, Diane J; Mangum, James B; Everitt, Jeffrey I; Recio, Leslie

Faiola, Brenda; Bauer, Alison K; Fuller, Elizabeth S; Wong, Victoria A; Pluta, Linda J; Abernethy, Diane J; Mangum, James B; Everitt, Jeffrey I; Recio, Leslie.

Affiliation

Faiola B; CIIT Centers for Health Research, Research Triangle Park, North Carolina 27709, USA. Brenda.Faiola@gsk.com

Toxicol Sci ; 75(2): 321-32, 2003 Oct.

Article in En | MEDLINE | ID: mdl-12857942

Subject(s)

Benzene/toxicity; DNA-Binding Proteins; Genetic Predisposition to Disease; Genetic Variation; Mutagens/toxicity; Protein Serine-Threonine Kinases/genetics; Administration, Inhalation; Animals; Apoptosis/drug effects; Benzene/administration & dosage; Bone Marrow Cells/drug effects; Bone Marrow Cells/metabolism; Bone Marrow Cells/pathology; Cyclin-Dependent Kinase Inhibitor p21; Cyclins/biosynthesis; Cyclins/genetics; Cytochrome P-450 CYP2E1/metabolism; DNA-Activated Protein Kinase; Dose-Response Relationship, Drug; Erythrocytes/drug effects; Erythrocytes/pathology; Homozygote; Mice; Mice, Inbred C57BL; Micronuclei, Chromosome-Defective/drug effects; Microsomes, Liver/drug effects; Microsomes, Liver/enzymology; Mutagens/administration & dosage; Nuclear Proteins; Protein Serine-Threonine Kinases/metabolism; RNA, Messenger/metabolism; Species Specificity

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Collection: 01-internacional Database: MEDLINE Main subject: Genetic Variation / Benzene / Protein Serine-Threonine Kinases / Genetic Predisposition to Disease / DNA-Binding Proteins / Mutagens Limits: Animals Language: En Journal: Toxicol Sci Journal subject: TOXICOLOGIA Year: 2003 Document type: Article Affiliation country: United States Country of publication: United States

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