Polarographic determination of flubendazole in spiked human urine and plasma.
Farmaco
; 58(8): 613-7, 2003 Aug.
Article
in En
| MEDLINE
| ID: mdl-12875892
ABSTRACT
The voltammetric behavior of flubendazole was studied using direct current (DCt), differential pulse (DPP) and alternating current (ACt) polarography. The drug manifests a cathodic wave in 20% v/v formic acid solution. The wave was characterized as being irreversible, diffusion-controlled with limited adsorption properties. The diffusion current-concentration relationship was found to be rectilinear over the range 3.2-14.4 microg/ml and 0.1 to 12.8 microg/ml, using DCt and DPP modes, respectively, with minimum detectability of 0.161 microg/ml (5.14 x 10(-7) M) and 0.0.057 microg/ml (1.82 x 10(-8) M) using DCt and DPP modes, respectively. Furthermore, the proposed method was applied to the in-vitro determination of flubendazole in spiked human urine and plasma adopting the DPP technique. The percentage recoveries were 100.20+/-0.62 and 97.42+/-0.95, respectively.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Mebendazole
/
Antinematodal Agents
Type of study:
Diagnostic_studies
Limits:
Humans
Language:
En
Journal:
Farmaco
Journal subject:
FARMACOLOGIA
/
QUIMICA
Year:
2003
Document type:
Article
Affiliation country:
Egypt