Decreased blood loss after cardiopulmonary bypass using heparin-coated circuit and 50% reduction of heparin dose.
Scand J Thorac Cardiovasc Surg
; 26(3): 177-85, 1992.
Article
in En
| MEDLINE
| ID: mdl-1287831
ABSTRACT
In a randomized, double-blind study of patients undergoing elective coronary artery grafting, the effect of heparin-coated circuit combined with 50% reduction of systemic heparin bolus was investigated. Ten patients comprised group HC (heparin-coated) and ten group C (controls). The mean total doses of heparin were 172 IU/kg in group HC and 416 IU/kg in group C and the respective protamine doses were 0.96 and 3.96 mg/kg (both p < 0.001). Activated clotting times during cardiopulmonary bypass were significantly shorter in group HC, and both intra- and postoperative bleeding was significantly less than in group C (7.7 vs. 11.7 ml/kg, p = 0.036, and 6.9 vs. 9.7 ml/kg, p = 0.004). Hemoglobin loss via the drains was 22.5 g in group HC and 43.7 g in group C (p < 0.005). Hemolysis at the end of bypass was significantly greater in group C. Apart from one perioperative myocardial infarction in group HC the postoperative course was uneventful. Use of a heparin-coated circuit is concluded to permit complication-free reduction of heparin and protamine doses and to decrease both intra- and postoperative bleeding, which may favorably influence the outcome of coronary artery grafting.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Heparin
/
Cardiopulmonary Bypass
/
Blood Loss, Surgical
Type of study:
Clinical_trials
Limits:
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Scand J Thorac Cardiovasc Surg
Year:
1992
Document type:
Article
Affiliation country:
Sweden