Mitochondrial apoptotic cell death and moderate superoxide generation upon selective activation of non-desensitizing AMPA receptors in hippocampal cultures.

Rego, A Cristina; Monteiro, Nuno M; Silva, Ana P; Gil, Joana; Malva, João O; Oliveira, Catarina R

Rego, A Cristina; Monteiro, Nuno M; Silva, Ana P; Gil, Joana; Malva, João O; Oliveira, Catarina R.

Affiliation

Rego AC; Institute of Biochemistry, Faculty of Medicine, University of Coimbra, Coimbra, Portugal. acrego@cnc.cj.uc.pt

J Neurochem ; 86(4): 792-804, 2003 Aug.

Article in En | MEDLINE | ID: mdl-12887678

Subject(s)

Apoptosis/physiology; Hippocampus/metabolism; Mitochondria/metabolism; Receptors, AMPA/metabolism; Superoxides/metabolism; Adenosine Diphosphate/metabolism; Adenosine Triphosphate/metabolism; Animals; Caspases/metabolism; Cells, Cultured; Cytochrome c Group/metabolism; Excitatory Amino Acid Agonists/pharmacology; Excitatory Amino Acid Antagonists/pharmacology; Hippocampus/cytology; Hippocampus/embryology; N-Methylaspartate/pharmacology; Necrosis; Neurons/cytology; Neurons/drug effects; Neurons/metabolism; Rats; Rats, Wistar; Receptors, AMPA/drug effects; Superoxide Dismutase/metabolism; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid/pharmacology

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Collection: 01-internacional Database: MEDLINE Main subject: Apoptosis / Receptors, AMPA / Superoxides / Hippocampus / Mitochondria Limits: Animals Language: En Journal: J Neurochem Year: 2003 Document type: Article Affiliation country: Portugal Country of publication: United kingdom

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