Synthesis and evaluation of novel bifunctional chelating agents based on 1,4,7,10-tetraazacyclododecane-N,N',N",N"'-tetraacetic acid for radiolabeling proteins.

Chappell, L L; Ma, D; Milenic, D E; Garmestani, K; Venditto, V; Beitzel, M P; Brechbiel, M W

Chappell, L L; Ma, D; Milenic, D E; Garmestani, K; Venditto, V; Beitzel, M P; Brechbiel, M W.

Affiliation

Chappell LL; Radioimmune & Inorganic Chemistry Section, National Cancer Institute/NIH, Bethesda, MD 20892-1002, USA.

Nucl Med Biol ; 30(6): 581-95, 2003 Aug.

Article in En | MEDLINE | ID: mdl-12900284

Subject(s)

Chelating Agents/pharmacokinetics; Colonic Neoplasms/metabolism; Heterocyclic Compounds, 1-Ring/pharmacokinetics; Isotope Labeling/methods; Lutetium/pharmacokinetics; Radioimmunoassay; Animals; Antibodies, Monoclonal; Cell Line, Tumor; Chelating Agents/chemical synthesis; Colonic Neoplasms/diagnostic imaging; Female; Heterocyclic Compounds, 1-Ring/chemistry; Humans; Metabolic Clearance Rate; Mice; Organ Specificity; Radioisotopes/pharmacokinetics; Radionuclide Imaging; Radiopharmaceuticals/chemical synthesis; Radiopharmaceuticals/pharmacokinetics; Tissue Distribution

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Collection: 01-internacional Database: MEDLINE Main subject: Radioimmunoassay / Chelating Agents / Colonic Neoplasms / Heterocyclic Compounds, 1-Ring / Isotope Labeling / Lutetium Type of study: Evaluation_studies Limits: Animals / Female / Humans Language: En Journal: Nucl Med Biol Journal subject: BIOLOGIA / MEDICINA NUCLEAR Year: 2003 Document type: Article Affiliation country: United States Country of publication: United States

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