Introduction of a benzoyl group onto 6-chloropurine riboside in aqueous solution and its application to the synthesis of nucleoside derivatives.
Nucleic Acids Symp Ser
; (44): 103-4, 2000.
Article
in En
| MEDLINE
| ID: mdl-12903289
ABSTRACT
A benzoyl group was introduced onto the 3'-hydroxyl group of 6-chloropurine riboside by treatment with benzoic anhydride in the presence of a base in aqueous solution. The product (3b) was converted to 9-(2,3-Di-deoxy-2-fluoro-beta-D-threo-pentofuranosyl)adenine (1, FddA) in 6 steps, including radical deoxygenation.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Purine Nucleosides
/
Dideoxyadenosine
/
Anti-HIV Agents
Language:
En
Journal:
Nucleic Acids Symp Ser
Year:
2000
Document type:
Article
Affiliation country:
Japan