Protein kinase C modulates tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by targeting the apical events of death receptor signaling.

Harper, Nicholas; Hughes, Michelle A; Farrow, Stuart N; Cohen, Gerald M; MacFarlane, Marion

Harper, Nicholas; Hughes, Michelle A; Farrow, Stuart N; Cohen, Gerald M; MacFarlane, Marion.

Affiliation

Harper N; Medical Research Council Toxicology Unit, University of Leicester, Hodgkin Bldg., P. O. Box 138, Lancaster Rd., Leicester LE1 9HN, United Kingdom.

J Biol Chem ; 278(45): 44338-47, 2003 Nov 07.

Article in En | MEDLINE | ID: mdl-12920112

Subject(s)

Adaptor Proteins, Signal Transducing; Apoptosis/drug effects; Membrane Glycoproteins/pharmacology; Protein Kinase C/metabolism; Receptors, Tumor Necrosis Factor/metabolism; Signal Transduction; Tumor Necrosis Factor-alpha/pharmacology; Apoptosis Regulatory Proteins; BH3 Interacting Domain Death Agonist Protein; Carrier Proteins/metabolism; Caspase 3; Caspase 8; Caspase 9; Caspases/metabolism; Cytochromes c/metabolism; Enzyme Activation/drug effects; Enzyme Inhibitors/pharmacology; Fas-Associated Death Domain Protein; HeLa Cells; Humans; I-kappa B Proteins/metabolism; Indoles/pharmacology; Maleimides/pharmacology; Mitochondria/metabolism; NF-KappaB Inhibitor alpha; NF-kappa B/metabolism; Phosphatidylserines/metabolism; Phosphorylation; Protein Kinase C/antagonists & inhibitors; Receptors, TNF-Related Apoptosis-Inducing Ligand; TNF-Related Apoptosis-Inducing Ligand; Tetradecanoylphorbol Acetate/pharmacology

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Collection: 01-internacional Database: MEDLINE Main subject: Protein Kinase C / Membrane Glycoproteins / Signal Transduction / Tumor Necrosis Factor-alpha / Apoptosis / Receptors, Tumor Necrosis Factor / Adaptor Proteins, Signal Transducing Limits: Humans Language: En Journal: J Biol Chem Year: 2003 Document type: Article Affiliation country: United kingdom Country of publication: United States

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