[The effect of the long-term treatment with calcium antagonists on myocardial function in patients with hypertension]. / Vliianie dlitel'nogo lecheniia antagonistami kal'tsiia na funktsional'noe sostoianie miokarda u bol'nykh gipertonicheskoi bolezn'iu.

Prolonged effect (6-12 months) of verapamil and nifedipine on the systolic and diastolic function of the myocardium was studied in 48 patients with hypertensive disease (stage II). It was established that in patients with a high ejection fraction (55% and more) the two drugs produce a distinct reduction of the pumping heart function. The two drugs increase the rate of early diastolic filling. They also may reduce the arterial pressure via different hemodynamic mechanisms: vasodilatation or via reduction of cardiac output.