Novel docosanoids inhibit brain ischemia-reperfusion-mediated leukocyte infiltration and pro-inflammatory gene expression.

Marcheselli, Victor L; Hong, Song; Lukiw, Walter J; Tian, Xiao Hua; Gronert, Karsten; Musto, Alberto; Hardy, Mattie; Gimenez, Juan M; Chiang, Nan; Serhan, Charles N; Bazan, Nicolas G

Marcheselli, Victor L; Hong, Song; Lukiw, Walter J; Tian, Xiao Hua; Gronert, Karsten; Musto, Alberto; Hardy, Mattie; Gimenez, Juan M; Chiang, Nan; Serhan, Charles N; Bazan, Nicolas G.

Affiliation

Marcheselli VL; Neuroscience Center of Excellence and Department of Ophthalmology, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA.

J Biol Chem ; 278(44): 43807-17, 2003 Oct 31.

Article in En | MEDLINE | ID: mdl-12923200

Subject(s)

Brain/pathology; Docosahexaenoic Acids/chemistry; Docosahexaenoic Acids/pharmacology; Leukocytes/metabolism; Reperfusion Injury; Animals; Anti-Inflammatory Agents, Non-Steroidal/pharmacology; Aspirin/pharmacology; Cells, Cultured; Cerebral Arteries/pathology; Cyclooxygenase 2; Hippocampus/metabolism; Humans; Immunohistochemistry; Interleukin-1/metabolism; Isoenzymes/metabolism; Leukocytes/pathology; Lipid Peroxidation; Membrane Proteins; Mice; Microscopy, Fluorescence; Models, Chemical; NF-kappa B/metabolism; Neurons/metabolism; Prostaglandin-Endoperoxide Synthases/metabolism; Signal Transduction; Stem Cells/metabolism; Time Factors

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Collection: 01-internacional Database: MEDLINE Main subject: Brain / Reperfusion Injury / Docosahexaenoic Acids / Leukocytes Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: J Biol Chem Year: 2003 Document type: Article Affiliation country: United States

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