Synthesis and structure-activity relationship studies of cinnamic acid-based novel thiazolidinedione antihyperglycemic agents.

Neogi, Partha; Lakner, Fredrick J; Medicherla, Satyanarayana; Cheng, Jin; Dey, Debendranath; Gowri, Maya; Nag, Bishwajit; Sharma, Somesh D; Pickford, Lesley B; Gross, Coleman

Neogi, Partha; Lakner, Fredrick J; Medicherla, Satyanarayana; Cheng, Jin; Dey, Debendranath; Gowri, Maya; Nag, Bishwajit; Sharma, Somesh D; Pickford, Lesley B; Gross, Coleman.

Affiliation

Neogi P; Department of Chemistry, Calyx Therapeutics Inc., 3513 Breakwater Avenue, Hayward, CA 94545, USA. p.neogi@att.net

Bioorg Med Chem ; 11(18): 4059-67, 2003 Sep 01.

Article in En | MEDLINE | ID: mdl-12927868

Subject(s)

Cinnamates/chemistry; Hypoglycemic Agents/chemical synthesis; Thiazolidinediones/chemical synthesis; Animals; Blood Glucose/analysis; Blood Glucose/metabolism; Diabetes Mellitus, Type 2/drug therapy; Diabetes Mellitus, Type 2/metabolism; Disease Models, Animal; Hypoglycemic Agents/pharmacology; Hypoglycemic Agents/therapeutic use; Isomerism; Mice; Phenylpropionates/chemical synthesis; Phenylpropionates/pharmacology; Prodrugs/chemical synthesis; Prodrugs/pharmacology; Receptors, Cytoplasmic and Nuclear/agonists; Receptors, Cytoplasmic and Nuclear/biosynthesis; Structure-Activity Relationship; Thiazolidinediones/pharmacology; Thiazolidinediones/therapeutic use; Transcription Factors/agonists; Transcription Factors/biosynthesis

Search on Google

Add to My VHL

XML

PubMed Links

Collection: 01-internacional Database: MEDLINE Main subject: Cinnamates / Thiazolidinediones / Hypoglycemic Agents Type of study: Prognostic_studies Limits: Animals Language: En Journal: Bioorg Med Chem Journal subject: BIOQUIMICA / QUIMICA Year: 2003 Document type: Article Affiliation country: United States Country of publication: United kingdom

Search on Google

Add to My VHL

XML

PubMed Links