Cyclosporin A treatment increases rat soleus muscle oxidative capacities.
Muscle Nerve
; 28(3): 324-9, 2003 Sep.
Article
in En
| MEDLINE
| ID: mdl-12929192
ABSTRACT
Previous studies suggested that administration of cyclosporin A (CsA), an immunosuppressive agent, contributes to the increased fatigability of heart transplant recipients. The aim of this study was to investigate whether CsA itself, without vehicle, affects the function of mitochondria maintained in situ, in rats treated with CsA (25mg/kg/day) dissolved in ethanol and olive oil. Treatment with CsA induced a 16% decrease in slow myosin heavy chain (MHC) associated with a 225% increase in fast MHCIIa. The proportion of fibers expressing type IIa MHC increased as a result of CsA treatment. Soleus from the CsA-treated animals showed an increase in both basal (+85%) and maximal (+37%) mitochondrial respiration (P < 0.001), consistent with a 24% increase in citrate synthase activity, whereas the apparent Km for adenosine diphosphate was unchanged. By itself, CsA has no deleterious effects on muscle oxidative capacity but induces alterations in energy metabolism in accordance with the increased proportion of fast-twitch oxidative fibers.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Heart Transplantation
/
Cyclosporine
/
Muscle, Skeletal
/
Muscle Fatigue
/
Immunosuppressive Agents
Limits:
Animals
Language:
En
Journal:
Muscle Nerve
Year:
2003
Document type:
Article
Affiliation country:
France