Intranasal immunization of humans with Streptococcus mutans antigens.
Oral Microbiol Immunol
; 18(5): 271-7, 2003 Oct.
Article
in En
| MEDLINE
| ID: mdl-12930517
ABSTRACT
To evaluate the effectiveness of a low dose of soluble or liposomal (L) glucosyltransferase-enriched preparation (E-GTF) in inducing mucosal immune responses after intranasal immunization, 12 adults were immunized on days 0 and 7 by the IN route with 62.5 microg of soluble E-GTF or L-E-GTF. An increase in the mean salivary IgA anti-E-GTF response (P < 0.03) was seen in the L-E-GTF but not the soluble E-GTF group. A significant increase (P < 0.05) in the mean specific IgA antibody activity was also seen in nasal wash from both groups. Although the nasal wash responses were higher in the L-E-GTF than in the soluble E-GTF group, they were not significantly different. The soluble E-GTF immunized group showed a higher serum IgG response than the L-E-GTF immunized group on day 90 (P < 0.05). These results indicate that as little as 62.5 microg of E-GTF, when given by the intranasal route, induced an IgA response in secretions.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Streptococcus mutans
/
Immunization
/
Antigens, Bacterial
Type of study:
Clinical_trials
Limits:
Adult
/
Humans
/
Middle aged
Language:
En
Journal:
Oral Microbiol Immunol
Journal subject:
ALERGIA E IMUNOLOGIA
/
MICROBIOLOGIA
/
ODONTOLOGIA
Year:
2003
Document type:
Article
Affiliation country:
United States