Fast proton spectroscopic imaging using steady-state free precession methods.
Magn Reson Med
; 50(3): 453-60, 2003 Sep.
Article
in En
| MEDLINE
| ID: mdl-12939751
ABSTRACT
Various pulse sequences for fast proton spectroscopic imaging (SI) using the steady-state free precession (SSFP) condition are proposed. The sequences use either only the FID-like signal S(1), only the echo-like signal S(2), or both signals in separate but adjacent acquisition windows. As in SSFP imaging, S(1) and S(2) are separated by spoiler gradients. RF excitation is performed by slice-selective or chemical shift-selective pulses. The signals are detected in absence of a B(0) gradient. Spatial localization is achieved by phase-encoding gradients which are applied prior to and rewound after each signal acquisition. Measurements with 2D or 3D spatial resolution were performed at 4.7 T on phantoms and healthy rat brain in vivo allowing the detection of uncoupled and J-coupled spins. The main advantages of SSFP based SI are the short minimum total measurement time (T(min)) and the high signal-to-noise ratio per unit measurement time (SNR(t)). The methods are of particular interest at higher magnetic field strength B(0), as TR can be reduced with increasing B(0) leading to a reduced T(min) and an increased SNR(t). Drawbacks consist of the limited spectral resolution, particularly at lower B(0), and the dependence of the signal intensities on T(1) and T(2). Further improvements are discussed including optimized data processing and signal detection under oscillating B(0) gradients leading to a further reduction in T(min).
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Brain
/
Magnetic Resonance Spectroscopy
Limits:
Animals
Language:
En
Journal:
Magn Reson Med
Journal subject:
DIAGNOSTICO POR IMAGEM
Year:
2003
Document type:
Article
Affiliation country:
Germany