Potent quinoxaline-based inhibitors of PDGF receptor tyrosine kinase activity. Part 1: SAR exploration and effective bioisosteric replacement of a phenyl substituent.
Bioorg Med Chem Lett
; 13(18): 3091-5, 2003 Sep 15.
Article
in En
| MEDLINE
| ID: mdl-12941341
ABSTRACT
Novel substituted 2-anilino- and 2-cycloalkylaminoquinoxalines have been found to be useful and selective inhibitors of PDGF-R autophosphorylation. Replacement of an anilino-substituent with substituted cyclohexylamino- or norbornylamino substituents led to significant improvements in the pharmacokinetic profile of these analogues.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Quinoxalines
/
Receptors, Platelet-Derived Growth Factor
Limits:
Humans
Language:
En
Journal:
Bioorg Med Chem Lett
Journal subject:
BIOQUIMICA
/
QUIMICA
Year:
2003
Document type:
Article
Affiliation country:
United States