Inactivation of Ret/Ptc1 oncoprotein and inhibition of papillary thyroid carcinoma cell proliferation by indolinone RPI-1.

Lanzi, C; Cassinelli, G; Cuccuru, G; Zaffaroni, N; Supino, R; Vignati, S; Zanchi, C; Yamamoto, M; Zunino, F

Lanzi, C; Cassinelli, G; Cuccuru, G; Zaffaroni, N; Supino, R; Vignati, S; Zanchi, C; Yamamoto, M; Zunino, F.

Affiliation

Lanzi C; Preclinical Chemotherapy and Pharmacology Unit, Department of Experimental Oncology, Istituto Nazionale Tumori, via G. Venezian 1, 20133 Milan, Italy. cinzia.lanzi@istitutotumori.mi.it

Cell Mol Life Sci ; 60(7): 1449-59, 2003 Jul.

Article in En | MEDLINE | ID: mdl-12943231

Subject(s)

Carcinoma, Papillary/pathology; Cell Division/drug effects; Indoles/pharmacology; Oncogene Proteins/antagonists & inhibitors; Proteins; Receptor Protein-Tyrosine Kinases/antagonists & inhibitors; Thyroid Neoplasms/pathology; Animals; Cell Cycle/drug effects; DNA, Neoplasm/drug effects; DNA, Neoplasm/genetics; Humans; Intracellular Signaling Peptides and Proteins; Kinetics; Membrane Proteins; Mice; Oncogene Proteins, Fusion; Patched Receptors; Patched-1 Receptor; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-ret; Receptors, Cell Surface; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction/drug effects; Signal Transduction/physiology; Telomerase/genetics; Tumor Cells, Cultured

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Collection: 01-internacional Database: MEDLINE Main subject: Thyroid Neoplasms / Carcinoma, Papillary / Proteins / Cell Division / Oncogene Proteins / Receptor Protein-Tyrosine Kinases / Indoles Limits: Animals / Humans Language: En Journal: Cell Mol Life Sci Journal subject: BIOLOGIA MOLECULAR Year: 2003 Document type: Article Affiliation country: Italy

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