Involvement of mitochondria in acetaminophen-induced apoptosis and hepatic injury: roles of cytochrome c, Bax, Bid, and caspases.

El-Hassan, Hasan; Anwar, Khurshid; Macanas-Pirard, Patricia; Crabtree, Mark; Chow, Sek C; Johnson, Victoria L; Lee, Pauline C; Hinton, Richard H; Price, Shirley C; Kass, George E N

El-Hassan, Hasan; Anwar, Khurshid; Macanas-Pirard, Patricia; Crabtree, Mark; Chow, Sek C; Johnson, Victoria L; Lee, Pauline C; Hinton, Richard H; Price, Shirley C; Kass, George E N.

Affiliation

El-Hassan H; School of Biomedical and Life Sciences, University of Surrey, Guildford, UK.

Toxicol Appl Pharmacol ; 191(2): 118-29, 2003 Sep 01.

Article in En | MEDLINE | ID: mdl-12946648

Subject(s)

Acetaminophen/toxicity; Analgesics, Non-Narcotic/toxicity; Apoptosis/drug effects; Mitochondria, Liver/drug effects; Proteins/metabolism; Proto-Oncogene Proteins c-bcl-2; Amino Acid Chloromethyl Ketones/pharmacology; Animals; BH3 Interacting Domain Death Agonist Protein; Carrier Proteins/metabolism; Caspase Inhibitors; Caspases/metabolism; Cytochrome c Group/metabolism; Enzyme Inhibitors/pharmacology; Injections, Intraperitoneal; Male; Mice; Mice, Inbred BALB C; Mitochondria, Liver/enzymology; Mitochondria, Liver/metabolism; Proto-Oncogene Proteins/metabolism; bcl-2-Associated X Protein

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Collection: 01-internacional Database: MEDLINE Main subject: Mitochondria, Liver / Proteins / Apoptosis / Analgesics, Non-Narcotic / Proto-Oncogene Proteins c-bcl-2 / Acetaminophen Limits: Animals Language: En Journal: Toxicol Appl Pharmacol Year: 2003 Document type: Article Affiliation country: United kingdom

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