Hypophosphatemic rickets and osteomalacia in polyostotic fibrous dysplasia.
J Pediatr Endocrinol Metab
; 16(6): 893-6, 2003.
Article
in En
| MEDLINE
| ID: mdl-12948303
ABSTRACT
A 17 year-old girl with polyostotic fibrous dysplasia and hypophosphatemia had inappropriately low tubular reabsorption of phosphate. She had radiological evidence of rickets and osteomalacia. The patient showed clinical improvement after treatment with phosphate supplementation, active vitamin D (calcitriol) and alendronate. It is postulated that either a phosphaturic substance elaborated from the dysplastic bone or target-organ (kidney) unresponsiveness may interfere with phosphate reabsorption in the renal tubule.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Osteomalacia
/
Fibrous Dysplasia, Polyostotic
/
Hypophosphatemia, Familial
Type of study:
Diagnostic_studies
/
Etiology_studies
Limits:
Child
/
Female
/
Humans
Language:
En
Journal:
J Pediatr Endocrinol Metab
Journal subject:
ENDOCRINOLOGIA
/
PEDIATRIA
Year:
2003
Document type:
Article
Affiliation country:
India