Expression of hypothalamic corticotropin-releasing hormone-like immunoreactivity in isolated ACTH deficiency: a report of an autopsied case.
J Endocrinol Invest
; 26(6): 556-9, 2003 Jun.
Article
in En
| MEDLINE
| ID: mdl-12952371
ABSTRACT
A 77-yr-old man died of metastising adenocarcinoma of the lung. He had been treated with hydrocortisone for isolated ACTH deficiency for 9 yr. At autopsy, the pituitary and the adrenal glands were atrophic. Lymphocyte infiltration was not observed in the pituitary, the adrenal and the thyroid glands. Immunohistochemistry revealed selective loss of ACTH-like immunoreactivity in the pituitary gland whereas CRH-immunoreactive cells were found in the paraventricular nucleus of the hypothalamus. This is the first report demonstrating immunohistochemical examinations of the pituitary and the hypothalamus in isolated ACTH deficiency.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Paraventricular Hypothalamic Nucleus
/
Corticotropin-Releasing Hormone
/
Adrenocorticotropic Hormone
Limits:
Aged
/
Humans
/
Male
Language:
En
Journal:
J Endocrinol Invest
Year:
2003
Document type:
Article
Affiliation country:
Japan
Publication country:
IT
/
ITALIA
/
ITALY
/
ITÁLIA