Efficacy of perioperative thromboprophylactic agents in the maintenance of anastamotic patency and survival of rat microvascular free groin flaps.
Otolaryngol Head Neck Surg
; 129(3): 176-82, 2003 Sep.
Article
in En
| MEDLINE
| ID: mdl-12958564
ABSTRACT
OBJECTIVES:
We sought to determine the thromboprophylactic effects of low-molecular-weight heparin (LMWH) and pentoxifylline.DESIGN:
Randomized blinded study. Materials and methods Sixty Sprague-Dawley rats were assigned to 1 of 4 treatment groups (1) control group (n = 15), (2) pentoxifylline group (n = 15), (3) LMWH group (n = 15), and (4) combined therapy group (n = 15). A groin/abdominal free flap was elevated in each, with division of the artery and microvascular repair The animals received therapy for 4 days preoperatively and 6 days postoperatively. Flaps were monitored visually, and on the seventh postoperative day, the flap was elevated, and the microvascular anastomosis was assessed for patency.RESULTS:
There was a statistically significant improvement in arterial patency in both pentoxifylline and LMWH groups compared with controls (P < 0.01) but no significant improvement with combined therapy (P > 0.05).CONCLUSIONS:
In this animal model, LMWH and pentoxifylline have significant thrombroprophylactic effects when used individually but not in combination.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pentoxifylline
/
Postoperative Care
/
Pulmonary Embolism
/
Thrombosis
/
Vascular Patency
/
Preoperative Care
/
Anastomosis, Surgical
/
Platelet Aggregation Inhibitors
/
Skin Transplantation
/
Heparin, Low-Molecular-Weight
Type of study:
Evaluation_studies
Limits:
Animals
Language:
En
Journal:
Otolaryngol Head Neck Surg
Year:
2003
Document type:
Article
Affiliation country:
United States