Continuous intrauterine compared with cyclic oral progestin administration in perimenopausal HRT.
Maturitas
; 46(1): 69-77, 2003 Sep 25.
Article
in En
| MEDLINE
| ID: mdl-12963171
ABSTRACT
OBJECTIVES:
Two hormone replacement therapy (HRT) regimens of combined oral estradiol with either continuous intrauterine or cyclic oral progestin were compared for 2 years.METHODS:
200 perimenopausal women randomly received an intrauterine system with continuous levonorgestrel release (20 microg/24 h) combined with oral estradiol (2 mg daily), or a cyclic oral regimen of norethisterone acetate (1 mg on day 13-22) and estradiol (days 1-21; 2 mg, days 22-28; 1 mg). Efficacy on endometrial protection, vaginal bleeding patterns, blood loss and practical use were compared during 26 cycles.RESULTS:
Endometrial protection was adequate in both regimens. The cyclic regimen induced a more regular bleeding pattern. The continuous local administration induced a reduction in bleeding (P=0.001) with an initial period of prolonged and frequent bleeding. 38% became amenorrhoeic. Women found both regimens acceptable.CONCLUSIONS:
Continuous intrauterine Levonorgestrel administration by using an intrauterine system can well be recommended for use in combination with oestrogen replacement therapy in perimenopausal women.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Climacteric
/
Estrogen Replacement Therapy
/
Norethindrone
Type of study:
Clinical_trials
Limits:
Female
/
Humans
/
Middle aged
Language:
En
Journal:
Maturitas
Year:
2003
Document type:
Article
Affiliation country:
Netherlands