Inhibition of evoked neurotransmitter release from rat hippocampus by a polypeptide toxin isolated from the marine snail Conus distans.
Neurochem Int
; 20(1): 69-74, 1992 Jan.
Article
in En
| MEDLINE
| ID: mdl-1304320
ABSTRACT
The active fraction, isolated and partially purified from the crude venom of the marine snail Conus distans, with a molecular mass of about 25 kDa, inhibits neurotransmitter release in rat hippocampus. This toxin (distans Toxin) inhibits the electrically evoked tritium labelled noradrenaline release from rat hippocampal slices in a dose and time dependent manner. The neurotransmitter release is mainly regulated by N-type of voltage sensitive Ca(2+)-channels. The distans toxin behaves as a partial antagonist of calcium in the buffer, possibly by competing with calcium for this type of voltage sensitive Ca(2+)-channels.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Norepinephrine
/
Hippocampus
/
Mollusk Venoms
/
Neurotoxins
Limits:
Animals
Language:
En
Journal:
Neurochem Int
Year:
1992
Document type:
Article
Affiliation country:
Belgium