Synthesis and receptor binding properties of fluoro- and iodo-substituted high affinity sigma receptor ligands: identification of potential PET and SPECT sigma receptor imaging agents.

de Costa, B; Radesca, L; Dominguez, C; Di Paolo, L; Bowen, W D

de Costa, B; Radesca, L; Dominguez, C; Di Paolo, L; Bowen, W D.

Affiliation

de Costa B; Laboratory of Medicinal Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892.

J Med Chem ; 35(12): 2221-30, 1992 Jun 12.

Article in En | MEDLINE | ID: mdl-1319493

Subject(s)

Benzomorphans/chemical synthesis; Ethylamines/chemical synthesis; Piperazines/chemical synthesis; Receptors, Opioid/metabolism; Tomography, Emission-Computed, Single-Photon; Tomography, Emission-Computed; Animals; Benzomorphans/metabolism; Brain/metabolism; Cyclazocine/analogs & derivatives; Cyclazocine/chemistry; Cyclazocine/metabolism; Ethylamines/metabolism; Fluorides; Guinea Pigs; Iodides; Piperazines/metabolism; Rats; Receptors, Opioid/analysis; Receptors, sigma; Synaptic Membranes/metabolism

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Collection: 01-internacional Database: MEDLINE Main subject: Piperazines / Benzomorphans / Tomography, Emission-Computed / Tomography, Emission-Computed, Single-Photon / Receptors, Opioid / Ethylamines Type of study: Diagnostic_studies Limits: Animals Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 1992 Document type: Article Country of publication: United States

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