Induction of cholangiocarcinoma in the Golden Syrian hamster using methylazoxymethyl acetate.

ABSTRACT

The Golden Syrian hamster, which has a bile acid profile similar to that of humans, is often used as an experimental model for cholangiocarcinoma. Unfortunately, most chemical carcinogens result in other tumour types also being induced which can be disadvantageous. In the present study, we describe the development of cholangiocarcinoma associated with precursor lesions of bile duct proliferation and dysplasia which occurred following a single i.v. dose of methylazoxymethyl acetate (10, 20 or 40 mg/kg body weight). Moreover, no other tumours were induced. This model may, therefore, prove useful in investigating the steps involved in the carcinogenesis of cholangiocarcinoma.