[Pathological status of catecholamines in the corpus striatum in hepatocerebral dystrophy (Wilson-Konovalov disease)]. / K patologii katekholaminov v polosatom tele pri gepatotserebral'noi distrofii (bolezni Vil'sona-Konovalova).
Zh Nevropatol Psikhiatr Im S S Korsakova
; 92(4): 8-10, 1992.
Article
in Ru
| MEDLINE
| ID: mdl-1333712
ABSTRACT
The content of catecholamines in the striatum was measured in 2 patients suffering from hepatocerebral dystrophy (Wilson-Konovalov disease). It is noted that in different clinical manifestations of the disease, the changes in the content of noradrenaline in the striatum varied. A male patient with marked tremor spreading manifested a considerable rise of the content of catecholamines, primarily in the n. caudatus. At the same time in a female patient with a grave akinetic -rigid syndrome and the signs of liver failure, the content of catecholamines, particularly dopamine, in the putamen was low. In view of this fact it is assumed that disorders of cerebral metabolism of catecholamines, dopamine in particular, evidently related to deposition of excess copper, leading to the changes of their content in basal ganglia underline the clinical pleomorphism of the disease and play the key role in the development of extrapyramidal motor disturbances characteristic of hepatocerebral dystrophy.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Dopamine
/
Norepinephrine
/
Copper
/
Corpus Striatum
/
Hepatolenticular Degeneration
Type of study:
Etiology_studies
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
Ru
Journal:
Zh Nevropatol Psikhiatr Im S S Korsakova
Journal subject:
NEUROLOGIA
/
PSIQUIATRIA
Year:
1992
Document type:
Article